Ergotamine derivatives: Considering the theoretical likelihood of ergotism, the fresh concurrent use of azithromycin that have ergot derivatives is not needed (get a hold of section 4.4).
No matter if neutropenia might have been in the accessibility rifabutin, an excellent causal link to combination which have azithromycin wasn’t founded (select Area cuatro
Caution is advised on the co-government of these medicines that have Azithromycin by the understood enhancing aftereffect of such drugs when utilized at the same time for the macrolid antibiotic erythromycin.
Co-management away from atorvastatin (ten milligrams each and every day) and you will azithromycin (500 milligrams daily) did not alter the plasma levels away from atorvastatin (considering an effective HMG CoA-reductase inhibition assay). However, post-marketing instances of rhabdomyolysis in the clients getting azithromycin having statins possess been stated.
In good pharmacokinetic communications studies during the healthy volunteers, zero https://datingmentor.org/nl/kik-overzicht extreme feeling is noticed toward plasma degrees of carbamazepine otherwise its effective metabolite inside the clients receiving concomitant azithromycin.
Even though good causal matchmaking was not founded, consideration are supplied to the new regularity away from overseeing prothrombin day whenever azithromycin can be used into the patients getting coumarin-style of dental anticoagulants
Cisapride is metabolized in the liver by the chemical CYP 3A4. As macrolides inhibit that it enzyme, concomitant government out-of cisapride may cause the increase out of QT period prolongation, ventricular arrhythmias and torsades de pointes.
Within the a great pharmacokinetic study exploring the results of 1 dosage out-of cimetidine, offered couple of hours prior to azithromycin, to the pharmacokinetics out-of azithromycin, no adjustment regarding azithromycin pharmacokinetics are viewed.
In the a great pharmacokinetic telecommunications studies, azithromycin did not change the anticoagulant aftereffect of one 15 milligrams dosage away from warfarin given in order to match volunteers. There were profile obtained on the post-purchases age potentiated anticoagulation after co-administration from azithromycin and you may coumarin-particular oral anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-management away from a good 600 milligrams unmarried amount of azithromycin and eight hundred milligrams efavirenz every day to possess 7 days didn’t produce any medically tall pharmacokinetic relations.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-administration of a single dosage of 1200 milligrams azithromycin didn’t come with mathematically significant effect on this new pharmacokinetics away from indinavir applied since 800 mg 3 x every single day for five months.
Into the match volunteers, co-government from azithromycin five hundred mg/day getting 3 days don’t bring about medically tall changes in the brand new pharmacokinetics and you will pharmacodynamics of a single fifteen mg amount away from midazolam.
Co-administration out-of azithromycin (1200 milligrams) and you can nelfinavir in the steady state (750 mg 3 times each and every day) resulted in increased azithromycin density. No medically extreme side effects had been seen without dose improvement required.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have advertised no proof of a relationship between azithromycin and you can terfenadine. There have been infrequent cases said where possibility of such as for instance a socializing could not feel entirely excluded; although not there is certainly zero certain research that like a relationships had happened.
