Subsequent, the brand new INTERSALT study, and therefore documented a confident relationship involving the urinary Na + /K + ratio and you may hypertension reported a loss in statistical significance of the fresh new relationship during the 49 of your 52 locations once variations for covariates and additionally years, sex and you will Bmi [thirty-two, 33]
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The https://datingranking.net/craigslist-hookup/ TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The modern analysis has numerous characteristics: (1) The brand new Dash -Salt trial is a thoroughly regulated feeding studies and you can conformity are continuously tracked, (2) This new crossover construction to own Na + intervention welcome participant’s in order to act as their unique control and you can diminished inter-people variability, (3) 24-h ambulatory blood pressure level tracks was drawn, (4) lack of new confounding aftereffects of antihypertensive mediations, and you may (5) 24-h urine try collection. The big limitation of your own expose data is the apparently modest try dimensions that possess diminished our analytical power to find small results of urinary Na + , K + , and you can Na + :K + proportion towards the SBP. As we don’t observe an instability in the standard properties, recurring confounding inside our investigation can be done.
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To close out the current research of one’s Dashboard–Sodium Demonstration suggests that dietary K + supplements isn’t regarding the down SBP and this the fresh new decrease when you look at the SBP seen following the Dashboard slimming down intervention happened alone regarding good reduction of new urinary Na + /K + removal ratio aside from this new salt sensitivity of blood pressure levels. The data do not hold the place out-of a-1:step 1 molar removal proportion regarding Na + /K + because hypertension lowering strategy during the United states African american and you will low-African Us citizens and you will support the DRI recommendation to not ever recommend every day K + consumption advice. Considering the limitations of your latest research as well as the constant conflict about your character out-of weight-loss K + for the blood pressure coming meticulously managed research is required to clarify the possibility feeling of weightloss K + and urinary Na + /K + removal ratio with the blood pressure level in both hypertensive and you can normotensive SS and SR users.
